5-year-old castrated male Greyhound
Extremely depressed, blind, pyrexic (39.6 C), Np pupillary light response bilaterally, no menace response bilaterally, no gag reflex, atrophy affecting masticatory muscles
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- study comprises transverse T1-weighted images pre- and post-gadolinium, T2-weighted images and FLAIR images, and sagittal T2-weighted image
- diffuse thickening of the pachymeninges over the entire cerebrum, most marked on the left
- lesion is hyperintense in T2-weighted images; marked enhancement after gadolinium administration
- herniation of the cerebellum
- signal intensity of muscles appears normal despite history of atrophy
- diffuse meningeal lesion suggests meningitis as the principal differential diagnosis; diffuse meningeal neoplasia is less likely
- cerebellar herniation is evidence of increased intracranial pressure
- MR lesions are compatible with signs
- CSF analysis is indicated as a means of confirming diagnosis; however, increased intracranial pressure is a contraindication to puncture of cerebellomedullary cistern; a lumbar puncture should be considered instead